Tag Archives: Oracea

Dr. Leslie Baumann Reviews Oracea and IPL for Rosacea Treatment

rosace expert dr. baumann

Dr. Leslie Baumann, Dermatologist

Leading dermatologist Leslie Baumann, M.D. reviews new rosacea treatment options, including low-dose doxycline (Oracea®) and intense-pulse light (IPL) therapy in a Miami Herald story published today.

Dr. Baumann pointed out that there are a variety of rosacea treatment options, including prescription medications. “Several years ago, a low dose form of doxycycline called Oracea® was developed. This drug is not a true antibiotic. Instead, it works through its anti-inflammatory properties. Oracea® can be used for long periods to prevent and treat rosacea without the complications associated with long-term antibiotic use.”

According to Dr. Baumann, a form of light treatment called Intense Pulsed Light (IPL) treatments has also been developed that has “revolutionized the treatment of rosacea“. IPL is a non-laser light source that can be used to treat several signs of rosacea. It was first approved for the treatment of fine dilated blood vessels (telangiectasias), but it may now be used to reduce persistent redness (erythema), flushing, and the bumps/pimples of rosacea subtype 2.

Dr. Baumann added that dermatologists may also prescribe a topical medication to be used in combination with oral medications or IPL treatments. Commonly prescribed rosacea medications include metronidazole (MetroGel®), azelaic acid (Finacea®) and sulfacetamide. Elidel®, a calcieurin inhibitior normally prescribed to control the inflammation associated with atopic dermatitis (eczema) may also be prescribed in some cases for rosacea.

Dr. Baumann added additional rosacea skin care tips to help rosacea sufferers manage their condition.

  • Avoid spicy foods and hot drinks
  • Drink coffee or tea cooled down or iced
  • Take omega-3 fatty acids that can fight redness and irritation. Sources include flaxseed and fatty fishes like salmon
  • Avoid are spa treatments like facials, some forms of chemical peels, microdermabrasion, hot wax, saunas and steam rooms, as they can irritate sensitive skin.

Rosacea affects up to 14 million Americans but it often goes undiagnosed. It is most common in the fair-skinned, but its cause is unknown. Rosacea usually appears on the skin of the face with redness of the nose, cheeks and forehead, bumps or pimples, broken blood vessels. It is frequently mistaken as acne.

Dr. Leslie Baumann is a board-certified dermatologist, author of Skin Type Solution, and the CEO of the Baumann Cosmetic & Research Institute in Miami Beach. Dr. Baumann also authors the twice-weekly Yahoo! Health blog “The Skin Guru”, with over 3 million readers, and writes a twice-monthly column in The Miami Herald. She authored Cosmetic Dermatology: Principles and Practice (McGraw-Hill, 2002), the world’s best-selling cosmetic dermatology textbook, as well as the New York Times best-selling book, The Skin Type Solution (Bantam Dell, 2006), which focuses on her revolutionary and proprietary skin typing system.

Rosacea Rosacea Treatment with Oral Doxycline (Oracea) Evaluated in ORCA Study


Rosacea Symptoms

Recently publicized results of the ORCA study, the largest clinical study of rosacea to date, showed that the treatment of rosacea subtype 2 (papulopustular rosacea) with Oracea® (doxycycline 40mg) lead to a significant reduction in pustules and papules.
This improvement in rosacea symptoms was seen when Oracea® was used alone (monotherapy) or in combination wither other topical medications, such as metronidazole (MetroGel®) or azelaic acid (Finacea®).
Hilary Baldwin, M.D.

Hilary Baldwin, M.D., Rosacea Expert

According to rosacea expert and study investigator Hilary Baldwin, M.D., “These results could change the way physicians treat rosacea.” Dr. Hilary Baldwin added that “ORCA confirms the safety of Oracea® and its effectiveness as a papulopustular rosacea treatment, even as monotherapy, with 3 out of 4 patients showing significant improvements over 12 weeks of treatment.”

The rosacea study evaluated 1421 patients with mild to severe papulopustular rosacea (rosacea subtype 2).

Oracea® is an oral medication that was developed to isolate doxycycline’s anti-inflammatory properties. This sub-antimicrobial dose, also called anti-inflammatory dose doxycycline, does not kill bacteria and does not lead to bacterial resistance. (Oracea® is a unique formulation of 30-mg immediate-release doxycyline and 10-mg delayed-release beads.)

ORCA stands for “Oracea® for Rosacea: A Community-Based Assessment”.

In the ORCA study, results found that the side effect profile of Oracea®, even in large populations, was consistent with that seen in controlled, clinical trials, with the most frequently reported side effects being mild to moderate nausea and diarrhea.

Rosacea is a chronic inflammatory skin disorder that primarily affects the face. It is prevalent amongst fair-skinned individuals who are 30 to 65 years old.  It often appears as skin lesions redness, visible blood vessels, papules and pustules in the middle of the face (forehead, nose, cheeks). Increased redness or flushing may result from certain rosacea triggers, such as alcohol, spicy food, sun exposure and hot showers. Stinging, burning and sensitivity of the skin and an intolerance to cosmetics are also very common and in some cases the eyes can become red, dry and itchy. There is presently no cure for rosacea, but topical and oral medications, as well as laser and light treatments, may reduce its signs and symptoms. Early diagnosis and treatment of rosacea can prevent its progression.

Oracea® is the only FDA approved oral medication for the treatment of rosacea. The ORCA trial was sponsored by Galderma Laboratories L.P., the manufacturer of  Oracea®. More information about the ORCA Trial is available from Galderma.

Important Safety Information About Oracea®

Oracea® is indicated for the treatment of only inflammatory lesions (papules and pustules) of rosacea in adult patients. You may experience intestinal upsets, sore throat or sinus infections/sinusitis when taking Oracea®. Do not take Oracea® if you are allergic to tetracyclines, and it may cause harm to a developing fetus; so do not take Oracea® if you are pregnant or breastfeeding.
When taking Oracea®, stay out of direct or artificial sunlight, and make sure you tell your doctor if you have stomach or GI problems, kidney disease, have a yeast or fungal infection, take blood thinners, take oral contraceptives, or take medicine to treat acne, psoriasis or seizures. Oracea® does not treat bacterial infections. Use Oracea® only as prescribed by your doctor.

For more information about Oracea®, see Full Prescribing Information.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit http://www.fda.gov/medwatch or call 1-800-FDA-1088.

Rosacea Treatments Outlined by Dermatologist, Jeffrey Poole, M.D.

Dermatologist, Jeffrey C. Poole, M.D.

Jeffrey C. Poole, M.D., Dermatologist

Dermatologist Jeffrey C. Poole, M.D. provides an overview of rosacea treatment options and describes how they are shaped by the type of rosacea.

“Erythrotelangiectatic rosacea (rosacea subtype 1) may be the initial phase of rosacea for many people.  Patients are red, flush easily from various stimuli such as alcohol, caffeine or temperature changes.  Sun protection is key to prevent long term progression of this stage, which may progress.  Coverup makeups can be used, and the newer mineral makeups seem to work well and are non-irritating”, says Dr. Poole.

Dr. Poole adds that for rosacea subtype 1, “the best treatment is the Pulsed Dye Laser  (PDL) or intense pulsed light (IPL).  These lasers and light sources target the blood vessels that are the cause of this condition.  Generally 3-4 treatments are sufficient for excellent results.”

Dr. Poole points out that most of the prescription medications for rosacea target papulopustular rosacea (rosacea subtype 2). Topical medications (metronidazole and azelaic acid) and oral medicines, such as doxcycycline (Oracea) and minocycline, are very effective in decreasing the red pimples and bumps. Long-term use of rosacea medications is the rule, and flares tend to recur as rosacea medications are weaned. Dr. Poole added that “pulsed dye laser treatment may improve rosacea subtype 2 symptoms and decrease the frequency of flares.”

Rhinophyma, seen with rosacea subtype 3, generally only occurs with men and less commonly than a few generations ago.  Treatment of rhinophyma can be with ablative lasers such as the CO2 laser, or with an electrocautery unit.  Dr. Poole stated that “Many patients find improvement in their sleep and less snoring, as well as a improved cosmetic appearance, with treatment.”

Dr. Poole is a board certified dermatologist in Metairie, Louisiana. In addition to his private dermatology practice, Poole Dermatology, Dr. Poole is also an Assistant Clinical Professor of Dermatology at both the LSU and Tulane Schools of Medicine, acting as their Pediatric and Adolescent specialist, and remains a board-certified pediatrician. He is a Fellow of the American Academy of Dermatology, the American Society of Dermatologic Surgery, the American Society of Laser Medicine and Surgery and the Society for Pediatric Dermatology.